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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL2
All Species:
1.52
Human Site:
S479
Identified Species:
2.78
UniProt:
Q92772
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92772
NP_003939.1
493
56019
S479
L
V
S
G
P
P
L
S
D
D
S
G
A
D
L
Chimpanzee
Pan troglodytes
XP_001153844
566
64313
L475
L
V
S
S
E
K
N
L
F
W
A
S
K
K
R
Rhesus Macaque
Macaca mulatta
NP_001129485
570
64691
L479
L
V
S
S
E
K
S
L
F
R
A
S
K
K
R
Dog
Lupus familis
XP_535605
561
63942
L480
V
T
S
E
K
S
L
L
Q
T
N
K
K
R
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9QUK0
568
64037
Q479
S
G
E
K
Y
L
L
Q
A
N
K
K
R
K
E
Rat
Rattus norvegicus
Q5XIT0
507
57117
K479
S
N
C
P
L
P
R
K
S
K
H
S
P
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512927
637
71445
T478
A
E
R
S
H
S
V
T
R
R
A
P
C
F
R
Chicken
Gallus gallus
P13863
303
34670
S293
Y
F
D
D
L
D
K
S
T
L
P
A
N
L
I
Frog
Xenopus laevis
P35567
302
34487
K292
P
Y
F
D
D
L
D
K
S
S
L
P
D
N
Q
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
L340
N
R
R
N
Y
N
N
L
R
K
F
N
Y
H
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23572
297
34420
F287
D
I
L
E
H
P
Y
F
N
G
F
Q
S
G
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784044
926
104004
Q508
M
I
H
E
K
T
L
Q
F
D
A
M
M
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
H284
N
A
R
A
A
L
E
H
E
Y
F
K
D
L
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
79.5
84
78.2
N.A.
74.8
81.8
N.A.
38.1
29.8
30.2
39.1
N.A.
27.9
N.A.
N.A.
33.5
Protein Similarity:
100
81.8
84.9
82.1
N.A.
80.2
86.9
N.A.
55.7
41.7
43.8
53.5
N.A.
41.7
N.A.
N.A.
44.2
P-Site Identity:
100
20
20
13.3
N.A.
6.6
13.3
N.A.
0
6.6
0
6.6
N.A.
13.3
N.A.
N.A.
13.3
P-Site Similarity:
100
26.6
26.6
26.6
N.A.
13.3
13.3
N.A.
20
13.3
6.6
6.6
N.A.
33.3
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
8
8
0
0
0
8
0
31
8
8
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
8
0
8
16
8
8
8
0
8
16
0
0
16
8
0
% D
% Glu:
0
8
8
24
16
0
8
0
8
0
0
0
0
0
8
% E
% Phe:
0
8
8
0
0
0
0
8
24
0
24
0
0
8
0
% F
% Gly:
0
8
0
8
0
0
0
0
0
8
0
8
0
8
8
% G
% His:
0
0
8
0
16
0
0
8
0
0
8
0
0
8
0
% H
% Ile:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
0
0
0
8
16
16
8
16
0
16
8
24
24
24
0
% K
% Leu:
24
0
8
0
16
24
31
31
0
8
8
0
0
16
31
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% M
% Asn:
16
8
0
8
0
8
16
0
8
8
8
8
8
8
0
% N
% Pro:
8
0
0
8
8
24
0
0
0
0
8
16
8
8
0
% P
% Gln:
0
0
0
0
0
0
0
16
8
0
0
8
0
0
8
% Q
% Arg:
0
8
24
0
0
0
8
0
16
16
0
0
8
8
31
% R
% Ser:
16
0
31
24
0
16
8
16
16
8
8
24
8
8
8
% S
% Thr:
0
8
0
0
0
8
0
8
8
8
0
0
0
0
0
% T
% Val:
8
24
0
0
0
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
8
8
0
0
16
0
8
0
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _